Bovine mycotic mastitis: A murine model
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Bovine mycotic mastitis : A murine model. / Guhad, F. A.; Jensen, H. E.; Hau, J.
In: Scandinavian Journal of Laboratory Animal Science, Vol. 23, No. SUPPL. 1, 1996, p. 415-418.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Bovine mycotic mastitis
T2 - A murine model
AU - Guhad, F. A.
AU - Jensen, H. E.
AU - Hau, J.
PY - 1996
Y1 - 1996
N2 - This study established a murine model for the study of mycotic mastitis. The mammary glands of BALB/c mice were inoculated on the fifth day of lactation with graded doses (104, 105 and 106 cells) of a pathogenic strain of Candida krusei isolated from bovine mastitis. The animals were killed 1, 2, 3, 4, and 5 days after inoculation. In the infected mammary glands, the pathological reaction consisted of primary' infiltration with heterophils and mononuclear cells, focal necrosis, formation of microabscesses, epithelial hyperplasia and some fibrosis. The severity of the changes was dose-dependent and increased with time after infection. An increase in the plasma concentrations of complement factors C1, C3c, C4 and C5, Factor B and alpha-2-macroglobulin suggested that an acute phase response and activation of the complement system had occurred as a result of the infection.
AB - This study established a murine model for the study of mycotic mastitis. The mammary glands of BALB/c mice were inoculated on the fifth day of lactation with graded doses (104, 105 and 106 cells) of a pathogenic strain of Candida krusei isolated from bovine mastitis. The animals were killed 1, 2, 3, 4, and 5 days after inoculation. In the infected mammary glands, the pathological reaction consisted of primary' infiltration with heterophils and mononuclear cells, focal necrosis, formation of microabscesses, epithelial hyperplasia and some fibrosis. The severity of the changes was dose-dependent and increased with time after infection. An increase in the plasma concentrations of complement factors C1, C3c, C4 and C5, Factor B and alpha-2-macroglobulin suggested that an acute phase response and activation of the complement system had occurred as a result of the infection.
UR - http://www.scopus.com/inward/record.url?scp=3242826604&partnerID=8YFLogxK
M3 - Journal article
AN - SCOPUS:3242826604
VL - 23
SP - 415
EP - 418
JO - Scandinavian Journal of Laboratory Animal Science
JF - Scandinavian Journal of Laboratory Animal Science
SN - 0901-3393
IS - SUPPL. 1
ER -
ID: 369375430