Comparison of immunospecific antibody response in young and old chickens immunized with human IgG

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Comparison of immunospecific antibody response in young and old chickens immunized with human IgG. / Bollen, Lise S.; Hau, Jann.

In: Laboratory Animals, Vol. 33, No. 1, 1999, p. 71-76.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Bollen, LS & Hau, J 1999, 'Comparison of immunospecific antibody response in young and old chickens immunized with human IgG', Laboratory Animals, vol. 33, no. 1, pp. 71-76. https://doi.org/10.1258/002367799780578435

APA

Bollen, L. S., & Hau, J. (1999). Comparison of immunospecific antibody response in young and old chickens immunized with human IgG. Laboratory Animals, 33(1), 71-76. https://doi.org/10.1258/002367799780578435

Vancouver

Bollen LS, Hau J. Comparison of immunospecific antibody response in young and old chickens immunized with human IgG. Laboratory Animals. 1999;33(1):71-76. https://doi.org/10.1258/002367799780578435

Author

Bollen, Lise S. ; Hau, Jann. / Comparison of immunospecific antibody response in young and old chickens immunized with human IgG. In: Laboratory Animals. 1999 ; Vol. 33, No. 1. pp. 71-76.

Bibtex

@article{d94f8e2d0c5346fe9fbad5bfdc1a55c6,
title = "Comparison of immunospecific antibody response in young and old chickens immunized with human IgG",
abstract = "Three groups of 18-month-old chickens and three groups of 5-month-old chickens were immunized with human immunoglobulin G (IgG) using one of three adjuvants in the first injection (Freund's Complete Adjuvant (FCA), Freunds Incomplete Adjuvant (FIA) and Hunter's TiterMax (HTM)) following the same immunization scheme. The specific antibody response in serum was measured by ELISA. In both older and younger chickens the serum antibody response in the FCA group reached a significantly higher level (P < 0.01) than in the FIA group and in the HTM group on week 5. The FCA group also had a significantly higher (P < 0.01) response on week 10 compared to the HTM group. Other than that, there was no significant difference between the three adjuvant groups in specific serum antibody response in older chickens. In the younger chickens the specific serum antibody response in the FCA group was significantly higher (P < 0.05) than the response in the HTM group. There was no significant difference in the chicken serum antibody response between the FCA and the FIA groups, nor was there a significant difference between the FIA and the HTM groups. Comparing the younger chickens and the older chickens immunized using the same adjuvant, the older chickens had consistently higher titres than the younger chickens, although the difference was not always significant.",
keywords = "Adjuvant, Chicken, Hen, Immunization, Old, Young",
author = "Bollen, {Lise S.} and Jann Hau",
year = "1999",
doi = "10.1258/002367799780578435",
language = "English",
volume = "33",
pages = "71--76",
journal = "Laboratory Animals",
issn = "0023-6772",
publisher = "SAGE Publications",
number = "1",

}

RIS

TY - JOUR

T1 - Comparison of immunospecific antibody response in young and old chickens immunized with human IgG

AU - Bollen, Lise S.

AU - Hau, Jann

PY - 1999

Y1 - 1999

N2 - Three groups of 18-month-old chickens and three groups of 5-month-old chickens were immunized with human immunoglobulin G (IgG) using one of three adjuvants in the first injection (Freund's Complete Adjuvant (FCA), Freunds Incomplete Adjuvant (FIA) and Hunter's TiterMax (HTM)) following the same immunization scheme. The specific antibody response in serum was measured by ELISA. In both older and younger chickens the serum antibody response in the FCA group reached a significantly higher level (P < 0.01) than in the FIA group and in the HTM group on week 5. The FCA group also had a significantly higher (P < 0.01) response on week 10 compared to the HTM group. Other than that, there was no significant difference between the three adjuvant groups in specific serum antibody response in older chickens. In the younger chickens the specific serum antibody response in the FCA group was significantly higher (P < 0.05) than the response in the HTM group. There was no significant difference in the chicken serum antibody response between the FCA and the FIA groups, nor was there a significant difference between the FIA and the HTM groups. Comparing the younger chickens and the older chickens immunized using the same adjuvant, the older chickens had consistently higher titres than the younger chickens, although the difference was not always significant.

AB - Three groups of 18-month-old chickens and three groups of 5-month-old chickens were immunized with human immunoglobulin G (IgG) using one of three adjuvants in the first injection (Freund's Complete Adjuvant (FCA), Freunds Incomplete Adjuvant (FIA) and Hunter's TiterMax (HTM)) following the same immunization scheme. The specific antibody response in serum was measured by ELISA. In both older and younger chickens the serum antibody response in the FCA group reached a significantly higher level (P < 0.01) than in the FIA group and in the HTM group on week 5. The FCA group also had a significantly higher (P < 0.01) response on week 10 compared to the HTM group. Other than that, there was no significant difference between the three adjuvant groups in specific serum antibody response in older chickens. In the younger chickens the specific serum antibody response in the FCA group was significantly higher (P < 0.05) than the response in the HTM group. There was no significant difference in the chicken serum antibody response between the FCA and the FIA groups, nor was there a significant difference between the FIA and the HTM groups. Comparing the younger chickens and the older chickens immunized using the same adjuvant, the older chickens had consistently higher titres than the younger chickens, although the difference was not always significant.

KW - Adjuvant

KW - Chicken

KW - Hen

KW - Immunization

KW - Old

KW - Young

UR - http://www.scopus.com/inward/record.url?scp=0033006261&partnerID=8YFLogxK

U2 - 10.1258/002367799780578435

DO - 10.1258/002367799780578435

M3 - Journal article

C2 - 10759395

AN - SCOPUS:0033006261

VL - 33

SP - 71

EP - 76

JO - Laboratory Animals

JF - Laboratory Animals

SN - 0023-6772

IS - 1

ER -

ID: 369374327