Intravenously administered lidocaine in therapeutic doses increases the intraspinal release of acetylcholine in rats

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Intravenously administered lidocaine in therapeutic doses increases the intraspinal release of acetylcholine in rats. / Abelson, Klas S P; Höglund, A Urban.

In: Neuroscience Letters, Vol. 317, No. 2, 11.01.2002, p. 93-6.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Abelson, KSP & Höglund, AU 2002, 'Intravenously administered lidocaine in therapeutic doses increases the intraspinal release of acetylcholine in rats', Neuroscience Letters, vol. 317, no. 2, pp. 93-6.

APA

Abelson, K. S. P., & Höglund, A. U. (2002). Intravenously administered lidocaine in therapeutic doses increases the intraspinal release of acetylcholine in rats. Neuroscience Letters, 317(2), 93-6.

Vancouver

Abelson KSP, Höglund AU. Intravenously administered lidocaine in therapeutic doses increases the intraspinal release of acetylcholine in rats. Neuroscience Letters. 2002 Jan 11;317(2):93-6.

Author

Abelson, Klas S P ; Höglund, A Urban. / Intravenously administered lidocaine in therapeutic doses increases the intraspinal release of acetylcholine in rats. In: Neuroscience Letters. 2002 ; Vol. 317, No. 2. pp. 93-6.

Bibtex

@article{252b31048a2744b9aae25d9a72ce685a,
title = "Intravenously administered lidocaine in therapeutic doses increases the intraspinal release of acetylcholine in rats",
abstract = "The local anesthetic lidocaine suppresses different pain conditions when administered systemically. Part of the antinociceptive effect appears to be mediated via receptor mechanisms. We have previously shown that muscarinic and nicotinic agonists that produce antinociception increase the intraspinal release of acetylcholine. In the present study it was hypothesized that systemically administered lidocaine is acting through the same mechanisms as cholinergic agonists and affects the intraspinal release of acetylcholine. Microdialysis probes were placed in anesthetized rats for sampling of acetylcholine. Ten and 30 mg/kg lidocaine injected intravenously significantly increased the intraspinal release of acetylcholine. The effect of lidocaine could be reduced by pretreatment with intraspinally administered atropine or mecamylamine. Our results suggest that the antinociceptive effect produced by systemically administered lidocaine is mediated through an action on muscarinic and nicotinic receptors.",
keywords = "Acetylcholine, Anesthetics, Local, Animals, Atropine, Choline, Dose-Response Relationship, Drug, Injections, Intravenous, Lidocaine, Male, Mecamylamine, Microdialysis, Muscarinic Agonists, Muscarinic Antagonists, Neostigmine, Nicotinic Agonists, Nicotinic Antagonists, Pain Threshold, Rats, Rats, Sprague-Dawley, Receptors, Muscarinic, Receptors, Nicotinic, Serotonin, Spinal Cord",
author = "Abelson, {Klas S P} and H{\"o}glund, {A Urban}",
year = "2002",
month = jan,
day = "11",
language = "English",
volume = "317",
pages = "93--6",
journal = "Neuroscience letters. Supplement",
issn = "0167-6253",
publisher = "Elsevier Ireland Ltd",
number = "2",

}

RIS

TY - JOUR

T1 - Intravenously administered lidocaine in therapeutic doses increases the intraspinal release of acetylcholine in rats

AU - Abelson, Klas S P

AU - Höglund, A Urban

PY - 2002/1/11

Y1 - 2002/1/11

N2 - The local anesthetic lidocaine suppresses different pain conditions when administered systemically. Part of the antinociceptive effect appears to be mediated via receptor mechanisms. We have previously shown that muscarinic and nicotinic agonists that produce antinociception increase the intraspinal release of acetylcholine. In the present study it was hypothesized that systemically administered lidocaine is acting through the same mechanisms as cholinergic agonists and affects the intraspinal release of acetylcholine. Microdialysis probes were placed in anesthetized rats for sampling of acetylcholine. Ten and 30 mg/kg lidocaine injected intravenously significantly increased the intraspinal release of acetylcholine. The effect of lidocaine could be reduced by pretreatment with intraspinally administered atropine or mecamylamine. Our results suggest that the antinociceptive effect produced by systemically administered lidocaine is mediated through an action on muscarinic and nicotinic receptors.

AB - The local anesthetic lidocaine suppresses different pain conditions when administered systemically. Part of the antinociceptive effect appears to be mediated via receptor mechanisms. We have previously shown that muscarinic and nicotinic agonists that produce antinociception increase the intraspinal release of acetylcholine. In the present study it was hypothesized that systemically administered lidocaine is acting through the same mechanisms as cholinergic agonists and affects the intraspinal release of acetylcholine. Microdialysis probes were placed in anesthetized rats for sampling of acetylcholine. Ten and 30 mg/kg lidocaine injected intravenously significantly increased the intraspinal release of acetylcholine. The effect of lidocaine could be reduced by pretreatment with intraspinally administered atropine or mecamylamine. Our results suggest that the antinociceptive effect produced by systemically administered lidocaine is mediated through an action on muscarinic and nicotinic receptors.

KW - Acetylcholine

KW - Anesthetics, Local

KW - Animals

KW - Atropine

KW - Choline

KW - Dose-Response Relationship, Drug

KW - Injections, Intravenous

KW - Lidocaine

KW - Male

KW - Mecamylamine

KW - Microdialysis

KW - Muscarinic Agonists

KW - Muscarinic Antagonists

KW - Neostigmine

KW - Nicotinic Agonists

KW - Nicotinic Antagonists

KW - Pain Threshold

KW - Rats

KW - Rats, Sprague-Dawley

KW - Receptors, Muscarinic

KW - Receptors, Nicotinic

KW - Serotonin

KW - Spinal Cord

M3 - Journal article

C2 - 11755248

VL - 317

SP - 93

EP - 96

JO - Neuroscience letters. Supplement

JF - Neuroscience letters. Supplement

SN - 0167-6253

IS - 2

ER -

ID: 48010609