Schistosomiasis (mansoni) has a negative impact on serum levels of estradiol, progesterone and prolactin in the female baboon (Papio cynocephalus anubis)
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Schistosomiasis (mansoni) has a negative impact on serum levels of estradiol, progesterone and prolactin in the female baboon (Papio cynocephalus anubis). / Farah, I. O.; Andersson, E.; Mwenda, J.; Wango, E.; Hau, J.
In: Scandinavian Journal of Laboratory Animal Science, Vol. 28, No. 4, 2001, p. 193-199.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Schistosomiasis (mansoni) has a negative impact on serum levels of estradiol, progesterone and prolactin in the female baboon (Papio cynocephalus anubis)
AU - Farah, I. O.
AU - Andersson, E.
AU - Mwenda, J.
AU - Wango, E.
AU - Hau, J.
PY - 2001
Y1 - 2001
N2 - The baboon (Papio cynocephalus anubis) is a well-established discriminative model for human reproduction as well as for studies of human schistosomiasis (mansoni). The present study examined the impact of experimental Schistosoma mansoni infection on ovarian hormones and prolactin in 28 female baboons (6-8 Kg). Serum concentrations of estradiol, progesterone and prolactin were recorded 2 and 11 weeks post secondary infection challenge dose (1000 cercariae). Lower than normal levels (serum estradiol < 50 pg/ml, serum progesterone < 1 ng/ml and serum prolactin < 2ng/ml) were found in the circulation, particularly 11 weeks after the challenge, when 20% of the animals had low hormone levels, which may be indicative of an anovulatory ovary. The results suggest that schistosomiasis may be a contributing factor to reduced fecundity among women in endemic regions.
AB - The baboon (Papio cynocephalus anubis) is a well-established discriminative model for human reproduction as well as for studies of human schistosomiasis (mansoni). The present study examined the impact of experimental Schistosoma mansoni infection on ovarian hormones and prolactin in 28 female baboons (6-8 Kg). Serum concentrations of estradiol, progesterone and prolactin were recorded 2 and 11 weeks post secondary infection challenge dose (1000 cercariae). Lower than normal levels (serum estradiol < 50 pg/ml, serum progesterone < 1 ng/ml and serum prolactin < 2ng/ml) were found in the circulation, particularly 11 weeks after the challenge, when 20% of the animals had low hormone levels, which may be indicative of an anovulatory ovary. The results suggest that schistosomiasis may be a contributing factor to reduced fecundity among women in endemic regions.
UR - http://www.scopus.com/inward/record.url?scp=23044498849&partnerID=8YFLogxK
M3 - Journal article
AN - SCOPUS:23044498849
VL - 28
SP - 193
EP - 199
JO - Scandinavian Journal of Laboratory Animal Science
JF - Scandinavian Journal of Laboratory Animal Science
SN - 0901-3393
IS - 4
ER -
ID: 369369713