Spinal cholinergic involvement after treatment with aspirin and paracetamol in rats
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Spinal cholinergic involvement after treatment with aspirin and paracetamol in rats. / Abelson, Klas S P; Kommalage, Mahinda; Höglund, A Urban.
In: Neuroscience Letters, Vol. 368, No. 1, 16.09.2004, p. 116-20.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Spinal cholinergic involvement after treatment with aspirin and paracetamol in rats
AU - Abelson, Klas S P
AU - Kommalage, Mahinda
AU - Höglund, A Urban
PY - 2004/9/16
Y1 - 2004/9/16
N2 - Aspirin and paracetamol have been shown to suppress non-inflammatory pain conditions like thermal, visceral and mechanical pain in mice and rats. The non-inflammatory antinociception appears to be mediated by central receptor mechanisms, such as the cholinergic system. In this study, we tested the hypothesis that the non-inflammatory antinociception of aspirin and paracetamol could be mediated by an increase of intraspinal acetylcholine release. Microdialysis probes were placed intraspinally in anesthetized rats for acetylcholine sampling. Subcutaneously administered aspirin 100 and 300 mg/kg increased, while paracetamol 300 mg/kg decreased intraspinal acetylcholine release. Intraspinal drug administration did not affect acetylcholine release. Our results suggest that an increased intraspinal acetylcholine release could be involved in part of the non-inflammatory pain suppression by aspirin, but not by paracetamol.
AB - Aspirin and paracetamol have been shown to suppress non-inflammatory pain conditions like thermal, visceral and mechanical pain in mice and rats. The non-inflammatory antinociception appears to be mediated by central receptor mechanisms, such as the cholinergic system. In this study, we tested the hypothesis that the non-inflammatory antinociception of aspirin and paracetamol could be mediated by an increase of intraspinal acetylcholine release. Microdialysis probes were placed intraspinally in anesthetized rats for acetylcholine sampling. Subcutaneously administered aspirin 100 and 300 mg/kg increased, while paracetamol 300 mg/kg decreased intraspinal acetylcholine release. Intraspinal drug administration did not affect acetylcholine release. Our results suggest that an increased intraspinal acetylcholine release could be involved in part of the non-inflammatory pain suppression by aspirin, but not by paracetamol.
KW - Acetaminophen
KW - Acetylcholine
KW - Analgesics, Non-Narcotic
KW - Animals
KW - Anti-Inflammatory Agents, Non-Steroidal
KW - Aspirin
KW - Body Temperature
KW - Injections, Subcutaneous
KW - Male
KW - Microdialysis
KW - Pain
KW - Parasympathetic Nervous System
KW - Rats
KW - Rats, Sprague-Dawley
KW - Spinal Cord
U2 - 10.1016/j.neulet.2004.06.070
DO - 10.1016/j.neulet.2004.06.070
M3 - Journal article
C2 - 15342146
VL - 368
SP - 116
EP - 120
JO - Neuroscience letters. Supplement
JF - Neuroscience letters. Supplement
SN - 0167-6253
IS - 1
ER -
ID: 48010486