Systemic immune response of young chickens orally immunized with bovine serum albumin

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Standard

Systemic immune response of young chickens orally immunized with bovine serum albumin. / Mayo, S. L.; Persdotter-Hedlund, G.; Tufvesson, M.; Hau, Jann.

In: In Vivo, Vol. 17, No. 3, 2003, p. 261-268.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Mayo, SL, Persdotter-Hedlund, G, Tufvesson, M & Hau, J 2003, 'Systemic immune response of young chickens orally immunized with bovine serum albumin', In Vivo, vol. 17, no. 3, pp. 261-268.

APA

Mayo, S. L., Persdotter-Hedlund, G., Tufvesson, M., & Hau, J. (2003). Systemic immune response of young chickens orally immunized with bovine serum albumin. In Vivo, 17(3), 261-268.

Vancouver

Mayo SL, Persdotter-Hedlund G, Tufvesson M, Hau J. Systemic immune response of young chickens orally immunized with bovine serum albumin. In Vivo. 2003;17(3):261-268.

Author

Mayo, S. L. ; Persdotter-Hedlund, G. ; Tufvesson, M. ; Hau, Jann. / Systemic immune response of young chickens orally immunized with bovine serum albumin. In: In Vivo. 2003 ; Vol. 17, No. 3. pp. 261-268.

Bibtex

@article{c7436793b64545819602112ac59c09a6,
title = "Systemic immune response of young chickens orally immunized with bovine serum albumin",
abstract = "The efficacy of oral immunization, with and without commercial adjuvants, to mount a systemic immune response in young chickens was studied. Bovine serum albumin (BSA) mixed with a pegylated C8/C10 mono/di-glyceride, (Softigen{\textregistered}), or Cholera toxin B-subunit (CTB), administered orally by gavage to 15-day-old chickens resulted in circulating immunospecific anti-BSA IgG, IgM and IgA antibodies. Continuous 5-day oral administration of BSA without adjuvant also resulted in immunospecific IgM and IgA antibodies in the circulation of chickens first immunized at 15 days of age; and immunospecific antibodies of all three classes in chickens first immunized when they were 22 days old. IgG and IgM serum concentrations were more than 4 to 10 times higher, respectively, in CTB- and Softigen-treated chickens as compared to chickens immunized without adjuvants. The IgA response in the orally immunized chickens seemed unaffected by CTB and Softigen. The antibody concentrations in chickens immunized subcutaneously with BSA emulsified in Freund's Incomplete Adjuvant (FIA) were approximately 10 times higher than those of the chickens orally immunized using CTB and Softigen.",
keywords = "Bovine serum albumin, Chickens, Cholera toxin B-subunit, Freund's adjuvant, Gallus domesticus, IgA, IgG, IgM, Oral immunization, Pegylated C8/C10 mono/diglyceride, Softigen",
author = "Mayo, {S. L.} and G. Persdotter-Hedlund and M. Tufvesson and Jann Hau",
year = "2003",
language = "English",
volume = "17",
pages = "261--268",
journal = "In Vivo",
issn = "0258-851X",
publisher = "International Institute of Anticancer Research",
number = "3",

}

RIS

TY - JOUR

T1 - Systemic immune response of young chickens orally immunized with bovine serum albumin

AU - Mayo, S. L.

AU - Persdotter-Hedlund, G.

AU - Tufvesson, M.

AU - Hau, Jann

PY - 2003

Y1 - 2003

N2 - The efficacy of oral immunization, with and without commercial adjuvants, to mount a systemic immune response in young chickens was studied. Bovine serum albumin (BSA) mixed with a pegylated C8/C10 mono/di-glyceride, (Softigen®), or Cholera toxin B-subunit (CTB), administered orally by gavage to 15-day-old chickens resulted in circulating immunospecific anti-BSA IgG, IgM and IgA antibodies. Continuous 5-day oral administration of BSA without adjuvant also resulted in immunospecific IgM and IgA antibodies in the circulation of chickens first immunized at 15 days of age; and immunospecific antibodies of all three classes in chickens first immunized when they were 22 days old. IgG and IgM serum concentrations were more than 4 to 10 times higher, respectively, in CTB- and Softigen-treated chickens as compared to chickens immunized without adjuvants. The IgA response in the orally immunized chickens seemed unaffected by CTB and Softigen. The antibody concentrations in chickens immunized subcutaneously with BSA emulsified in Freund's Incomplete Adjuvant (FIA) were approximately 10 times higher than those of the chickens orally immunized using CTB and Softigen.

AB - The efficacy of oral immunization, with and without commercial adjuvants, to mount a systemic immune response in young chickens was studied. Bovine serum albumin (BSA) mixed with a pegylated C8/C10 mono/di-glyceride, (Softigen®), or Cholera toxin B-subunit (CTB), administered orally by gavage to 15-day-old chickens resulted in circulating immunospecific anti-BSA IgG, IgM and IgA antibodies. Continuous 5-day oral administration of BSA without adjuvant also resulted in immunospecific IgM and IgA antibodies in the circulation of chickens first immunized at 15 days of age; and immunospecific antibodies of all three classes in chickens first immunized when they were 22 days old. IgG and IgM serum concentrations were more than 4 to 10 times higher, respectively, in CTB- and Softigen-treated chickens as compared to chickens immunized without adjuvants. The IgA response in the orally immunized chickens seemed unaffected by CTB and Softigen. The antibody concentrations in chickens immunized subcutaneously with BSA emulsified in Freund's Incomplete Adjuvant (FIA) were approximately 10 times higher than those of the chickens orally immunized using CTB and Softigen.

KW - Bovine serum albumin

KW - Chickens

KW - Cholera toxin B-subunit

KW - Freund's adjuvant

KW - Gallus domesticus

KW - IgA

KW - IgG

KW - IgM

KW - Oral immunization

KW - Pegylated C8/C10 mono/diglyceride

KW - Softigen

UR - http://www.scopus.com/inward/record.url?scp=0042122467&partnerID=8YFLogxK

M3 - Journal article

C2 - 12929578

AN - SCOPUS:0042122467

VL - 17

SP - 261

EP - 268

JO - In Vivo

JF - In Vivo

SN - 0258-851X

IS - 3

ER -

ID: 369368272