The utility of fecal corticosterone metabolites and animal welfare assessment protocols as predictive parameters of tumor development and animal welfare in a murine xenograft model

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

The utility of fecal corticosterone metabolites and animal welfare assessment protocols as predictive parameters of tumor development and animal welfare in a murine xenograft model. / Jacobsen, Kirsten Rosenmaj; Jørgensen, Pernille Schønning; Pipper, Christian Bressen; Steffensen, Astrid Margrethe; Hau, Jann; Abelson, Klas S P.

In: In Vivo, Vol. 27, No. 2, 2013, p. 189-96.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Jacobsen, KR, Jørgensen, PS, Pipper, CB, Steffensen, AM, Hau, J & Abelson, KSP 2013, 'The utility of fecal corticosterone metabolites and animal welfare assessment protocols as predictive parameters of tumor development and animal welfare in a murine xenograft model', In Vivo, vol. 27, no. 2, pp. 189-96. <http://www.ncbi.nlm.nih.gov/pubmed/23422477>

APA

Jacobsen, K. R., Jørgensen, P. S., Pipper, C. B., Steffensen, A. M., Hau, J., & Abelson, K. S. P. (2013). The utility of fecal corticosterone metabolites and animal welfare assessment protocols as predictive parameters of tumor development and animal welfare in a murine xenograft model. In Vivo, 27(2), 189-96. http://www.ncbi.nlm.nih.gov/pubmed/23422477

Vancouver

Jacobsen KR, Jørgensen PS, Pipper CB, Steffensen AM, Hau J, Abelson KSP. The utility of fecal corticosterone metabolites and animal welfare assessment protocols as predictive parameters of tumor development and animal welfare in a murine xenograft model. In Vivo. 2013;27(2):189-96.

Author

Jacobsen, Kirsten Rosenmaj ; Jørgensen, Pernille Schønning ; Pipper, Christian Bressen ; Steffensen, Astrid Margrethe ; Hau, Jann ; Abelson, Klas S P. / The utility of fecal corticosterone metabolites and animal welfare assessment protocols as predictive parameters of tumor development and animal welfare in a murine xenograft model. In: In Vivo. 2013 ; Vol. 27, No. 2. pp. 189-96.

Bibtex

@article{0ab04461f605487e89eb771d8e853ee7,
title = "The utility of fecal corticosterone metabolites and animal welfare assessment protocols as predictive parameters of tumor development and animal welfare in a murine xenograft model",
abstract = "The aim of the present study was to evaluate the utility of various non-invasive parameters for the prediction of tumor development and animal welfare in a murine xenograft model in male C.B-17 SCID (C.B-Igh-1(b)/IcrTac-Prkdc(scid)) mice. The study showed that body weight, food and water consumption, and an animal welfare assessment (AWA) protocol revealed marked differences between control and cancer lines as the size of the tumor increased. However, only the AWA protocol was effective in predicting the tumor size and the level of fecal corticosterone metabolites (FCM). FCM levels were, however, negatively-correlated to the AWA score, and the tumor size, both when evaluated on a given day and when accumulated over the entire period. In conclusion, the present study demonstrated that body weight and food and water consumption were negatively-affected as tumor developed but only the animal welfare protocol could be used to predict tumor size.",
author = "Jacobsen, {Kirsten Rosenmaj} and J{\o}rgensen, {Pernille Sch{\o}nning} and Pipper, {Christian Bressen} and Steffensen, {Astrid Margrethe} and Jann Hau and Abelson, {Klas S P}",
year = "2013",
language = "English",
volume = "27",
pages = "189--96",
journal = "In Vivo",
issn = "0258-851X",
publisher = "International Institute of Anticancer Research",
number = "2",

}

RIS

TY - JOUR

T1 - The utility of fecal corticosterone metabolites and animal welfare assessment protocols as predictive parameters of tumor development and animal welfare in a murine xenograft model

AU - Jacobsen, Kirsten Rosenmaj

AU - Jørgensen, Pernille Schønning

AU - Pipper, Christian Bressen

AU - Steffensen, Astrid Margrethe

AU - Hau, Jann

AU - Abelson, Klas S P

PY - 2013

Y1 - 2013

N2 - The aim of the present study was to evaluate the utility of various non-invasive parameters for the prediction of tumor development and animal welfare in a murine xenograft model in male C.B-17 SCID (C.B-Igh-1(b)/IcrTac-Prkdc(scid)) mice. The study showed that body weight, food and water consumption, and an animal welfare assessment (AWA) protocol revealed marked differences between control and cancer lines as the size of the tumor increased. However, only the AWA protocol was effective in predicting the tumor size and the level of fecal corticosterone metabolites (FCM). FCM levels were, however, negatively-correlated to the AWA score, and the tumor size, both when evaluated on a given day and when accumulated over the entire period. In conclusion, the present study demonstrated that body weight and food and water consumption were negatively-affected as tumor developed but only the animal welfare protocol could be used to predict tumor size.

AB - The aim of the present study was to evaluate the utility of various non-invasive parameters for the prediction of tumor development and animal welfare in a murine xenograft model in male C.B-17 SCID (C.B-Igh-1(b)/IcrTac-Prkdc(scid)) mice. The study showed that body weight, food and water consumption, and an animal welfare assessment (AWA) protocol revealed marked differences between control and cancer lines as the size of the tumor increased. However, only the AWA protocol was effective in predicting the tumor size and the level of fecal corticosterone metabolites (FCM). FCM levels were, however, negatively-correlated to the AWA score, and the tumor size, both when evaluated on a given day and when accumulated over the entire period. In conclusion, the present study demonstrated that body weight and food and water consumption were negatively-affected as tumor developed but only the animal welfare protocol could be used to predict tumor size.

M3 - Journal article

C2 - 23422477

VL - 27

SP - 189

EP - 196

JO - In Vivo

JF - In Vivo

SN - 0258-851X

IS - 2

ER -

ID: 46436174