Transdermal Fentanyl Solution Provides Long-term Analgesia in the Hind-paw Incisional Model of Postoperative Pain in Male Rats

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

Transdermal Fentanyl Solution Provides Long-term Analgesia in the Hind-paw Incisional Model of Postoperative Pain in Male Rats. / Clemensen, Johanne; Rasmussen, Lena V.; Abelson, Klas S.P.

In: In Vivo, Vol. 32, No. 4, 01.07.2018, p. 713-719.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Clemensen, J, Rasmussen, LV & Abelson, KSP 2018, 'Transdermal Fentanyl Solution Provides Long-term Analgesia in the Hind-paw Incisional Model of Postoperative Pain in Male Rats', In Vivo, vol. 32, no. 4, pp. 713-719. https://doi.org/10.21873/invivo.11299

APA

Clemensen, J., Rasmussen, L. V., & Abelson, K. S. P. (2018). Transdermal Fentanyl Solution Provides Long-term Analgesia in the Hind-paw Incisional Model of Postoperative Pain in Male Rats. In Vivo, 32(4), 713-719. https://doi.org/10.21873/invivo.11299

Vancouver

Clemensen J, Rasmussen LV, Abelson KSP. Transdermal Fentanyl Solution Provides Long-term Analgesia in the Hind-paw Incisional Model of Postoperative Pain in Male Rats. In Vivo. 2018 Jul 1;32(4):713-719. https://doi.org/10.21873/invivo.11299

Author

Clemensen, Johanne ; Rasmussen, Lena V. ; Abelson, Klas S.P. / Transdermal Fentanyl Solution Provides Long-term Analgesia in the Hind-paw Incisional Model of Postoperative Pain in Male Rats. In: In Vivo. 2018 ; Vol. 32, No. 4. pp. 713-719.

Bibtex

@article{fe6705afadcc422299eab02be706bddd,
title = "Transdermal Fentanyl Solution Provides Long-term Analgesia in the Hind-paw Incisional Model of Postoperative Pain in Male Rats",
abstract = "Background: A recently developed transdermal fentanyl solution was hypothesized to be effective for noninvasive postoperative analgesia in rats. Materials and Methods: Thirty-nine male Sprague-Dawley rats were treated once with 0.1, 0.33 or 1.0 mg/kg transdermal fentanyl solution at the skin of the scruff 1 h prior to subjected to hind-paw surgery, and compared to non-treated animals. All rats were tested for nociceptive response in the electronic von Frey (EVF) test between 1 and 72 h postoperatively, and assessed daily with regards to facial expression, body weight changes and welfare score. Results: Fentanyl treatment at all doses significantly reduced nociceptive response in the EVF test throughout the 72 h of experimentation, reduced facial expressions on all days postoperatively, slightly reduced the body weight and improved postoperative welfare parameters. Conclusion: The present study indicates that transdermal fentanyl solution seems to be an effective, non-invasive and long-lasting analgesic regimen in male rats.",
keywords = "Analgesia, Fentanyl, Laboratory rats, Pain, Transdermal",
author = "Johanne Clemensen and Rasmussen, {Lena V.} and Abelson, {Klas S.P.}",
year = "2018",
month = jul,
day = "1",
doi = "10.21873/invivo.11299",
language = "English",
volume = "32",
pages = "713--719",
journal = "In Vivo",
issn = "0258-851X",
publisher = "International Institute of Anticancer Research",
number = "4",

}

RIS

TY - JOUR

T1 - Transdermal Fentanyl Solution Provides Long-term Analgesia in the Hind-paw Incisional Model of Postoperative Pain in Male Rats

AU - Clemensen, Johanne

AU - Rasmussen, Lena V.

AU - Abelson, Klas S.P.

PY - 2018/7/1

Y1 - 2018/7/1

N2 - Background: A recently developed transdermal fentanyl solution was hypothesized to be effective for noninvasive postoperative analgesia in rats. Materials and Methods: Thirty-nine male Sprague-Dawley rats were treated once with 0.1, 0.33 or 1.0 mg/kg transdermal fentanyl solution at the skin of the scruff 1 h prior to subjected to hind-paw surgery, and compared to non-treated animals. All rats were tested for nociceptive response in the electronic von Frey (EVF) test between 1 and 72 h postoperatively, and assessed daily with regards to facial expression, body weight changes and welfare score. Results: Fentanyl treatment at all doses significantly reduced nociceptive response in the EVF test throughout the 72 h of experimentation, reduced facial expressions on all days postoperatively, slightly reduced the body weight and improved postoperative welfare parameters. Conclusion: The present study indicates that transdermal fentanyl solution seems to be an effective, non-invasive and long-lasting analgesic regimen in male rats.

AB - Background: A recently developed transdermal fentanyl solution was hypothesized to be effective for noninvasive postoperative analgesia in rats. Materials and Methods: Thirty-nine male Sprague-Dawley rats were treated once with 0.1, 0.33 or 1.0 mg/kg transdermal fentanyl solution at the skin of the scruff 1 h prior to subjected to hind-paw surgery, and compared to non-treated animals. All rats were tested for nociceptive response in the electronic von Frey (EVF) test between 1 and 72 h postoperatively, and assessed daily with regards to facial expression, body weight changes and welfare score. Results: Fentanyl treatment at all doses significantly reduced nociceptive response in the EVF test throughout the 72 h of experimentation, reduced facial expressions on all days postoperatively, slightly reduced the body weight and improved postoperative welfare parameters. Conclusion: The present study indicates that transdermal fentanyl solution seems to be an effective, non-invasive and long-lasting analgesic regimen in male rats.

KW - Analgesia

KW - Fentanyl

KW - Laboratory rats

KW - Pain

KW - Transdermal

UR - http://www.scopus.com/inward/record.url?scp=85050022128&partnerID=8YFLogxK

U2 - 10.21873/invivo.11299

DO - 10.21873/invivo.11299

M3 - Journal article

C2 - 29936450

AN - SCOPUS:85050022128

VL - 32

SP - 713

EP - 719

JO - In Vivo

JF - In Vivo

SN - 0258-851X

IS - 4

ER -

ID: 213323572