An overview of animal models in experimental schistosomiasis and refinements in the use of non-human primates
Research output: Contribution to journal › Review › Research › peer-review
The complex nature of the schistosome parasite and its interaction with the mammalian host necessitates the continued use of live intact animal models in schistosomiasis research. This review acknowledges this necessity and highlights some of the important insights into the pathogenesis of the disease that have been gained from using various animal models. The use of non-human primates as more relevant models of human schistosomiasis is stated. In addition, the importance of animal welfare consideration when using primates for research is emphasized. Finally, some guidelines for the refined capture, handling and early humane end-points for non-human primates to be used in experimental schistosomiasis are suggested.
Original language | English |
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Journal | Laboratory Animals |
Volume | 35 |
Issue number | 3 |
Pages (from-to) | 205-212 |
Number of pages | 8 |
ISSN | 0023-6772 |
DOIs | |
Publication status | Published - 2001 |
- Animal models, Animal welfare, Humane endpoints, Non-human primates, Refinement, Schistosoma mansoni
Research areas
ID: 369371308